Related Experiment Video
Updated: Jan 22, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
9.9K
Unrelated Death After Colorectal Cancer Screening: Implications for Improving Colonoscopy Referrals
Andrew Gawron1, Klaus Bielefeldt1
1is a Gastroenterologist at the Salt Lake City Specialty Care Center of Innovation, and is Chief of the Gastroenterology Section, both at the VA George E. Wahlen VA Medical Center in Salt Lake City, Utah. Andrew Gawron is an Associate Professor at the University of Utah.
Summary
Colonoscopy screening
Area of Science:
- Gastroenterology
- Oncology
- Public Health
Background:
- Colonoscopy is a key screening tool for colorectal cancer.
- Assessing the net benefit of screening is crucial for optimizing patient outcomes.
Purpose of the Study:
- To evaluate the impact of mortality within five years on the overall benefit of colonoscopy screening.
- To inform healthcare providers on refining screening recommendations for individual veterans.
Main Methods:
- Analysis of mortality data in veterans following index colonoscopy.
- Assessment of factors influencing screening benefit, including cancer risk, comorbidities, and age.
Main Results:
- Observed mortality within five years post-colonoscopy reduced the overall effectiveness of the screening procedure.
- This finding suggests a need for personalized benefit assessment.
Conclusions:
- Healthcare providers should conduct a detailed evaluation of individual veterans' potential reduced screening benefits.
- Consideration of cancer risk, comorbidity burden, and age is essential for tailoring colonoscopy screening decisions.
Related Concept Videos
01:25Endoscopic Procedures II: Colonoscopy
659
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
659
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
392
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
392
01:30Overview of Cell Death
9.6K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.6K
01:18Autophagic Cell Death
4.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K
02:07Improving Translational Accuracy
14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K
02:07Improving Translational Accuracy
3.6K
3.6K