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Bilateral Transient Myopia with Sulfasalazine Treatment
Tal Paz1, Daniel Rappoport1,2, Assaf Hilely1
1Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel.
Clinical Medicine Insights. Case Reports
|July 2, 2019
Summary
Transient myopia occurred in a patient taking Sulfasalazine for ulcerative colitis. Vision improved rapidly after discontinuing the drug, suggesting a link between Sulfasalazine and temporary vision changes.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Drug-induced myopia is a rare but documented side effect, primarily associated with sulfonamide-based medications.
- Sulfasalazine, a sulfa drug derivative, is used to treat inflammatory bowel diseases like ulcerative colitis.
Observation:
- A Caucasian female with ulcerative colitis experienced sudden, significant bilateral myopia (-4 Diopters) after starting Sulfasalazine.
- Ocular examination revealed no other abnormalities besides the induced myopia.
Findings:
- The patient's myopia resolved within four days of discontinuing Sulfasalazine.
- Best corrected visual acuity improved significantly, with refractive error reducing to -0.75 D (RE) and -0.50 D (LE).
Implications:
- This case highlights Sulfasalazine as a potential cause of transient myopia.
- Clinicians should consider drug-induced myopia in patients presenting with acute visual changes, especially when initiating sulfa-based medications.
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