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Association between critical limb ischemia and arterial stiffness measured by brachial artery oscillometry

Daniel Mendes-Pinto1,2, José Márcio Ribeiro2,3, Maria da Glória Rodrigues-Machado2

  • 1Hospital Felício Rocho, Departamento de Cirurgia Vascular, Belo Horizonte, MG, Brasil.

Jornal Vascular Brasileiro
|July 2, 2019
PubMed

Insights

Patients with critical limb ischemia (CLI) exhibit higher arterial stiffness. Reduced ankle-brachial index (ABI) predicts increased augmentation index (AIx@75), suggesting implications for advanced atherosclerosis prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Tools

Background:

  • Elevated arterial stiffness is a known risk factor for cardiovascular mortality.
  • The specific link between arterial stiffness and critical limb ischemia (CLI) requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness indices and the severity of limb ischemia, as assessed by the ankle-brachial index (ABI).

Main Methods:

  • A cross-sectional study design was employed, comparing patients with CLI to a control group.
  • Arterial stiffness was quantified using brachial artery oscillometry, measuring pulse wave velocity (PWV) and augmentation index (AIx@75).
  • Multiple linear regression analysis identified predictors of arterial stiffness.

Main Results:

  • CLI patients demonstrated significantly higher PWV and AIx@75 compared to controls.
  • A significant inverse relationship was observed between AIx@75 and ABI.
  • Reduced ABI was identified as a predictor of elevated AIx@75 levels.

Conclusions:

  • Critical limb ischemia is associated with heightened arterial stiffness, as measured by brachial artery oscillometry.
  • The ankle-brachial index (ABI) serves as a predictor for increased augmentation index (AIx@75) in CLI patients.
  • Elevated AIx@75 in CLI may indicate a poorer prognosis for patients with advanced atherosclerosis.
Abstract

Keywords:
ankle brachial indexarterial stiffnessperipheral arterial diseasepulse wave analysis

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