Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

Mutation of hydrophobic residues in the factor Va C1 and C2 domains blocks membrane-dependent prothrombin activation.

Journal of thrombosis and haemostasis : JTH·2005

Soluble phosphatidylserine binds to a single identified site in the C2 domain of human factor Va.

Biochemistry·2001

Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding.

Thrombosis and haemostasis·2001

Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues.

Proceedings of the National Academy of Sciences of the United States of America·2001

Hemophilic factor VIII C1- and C2-domain missense mutations and their modeling to the 1.5-angstrom human C2-domain crystal structure.

Blood·2000

Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis.

Biochemistry·2000

CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist.

Blood·2026

Thrombin-mediated AutoRegulation of FVIII-mimetic antibodies enabling dynamic control of the hemostatic response.

Blood·2026

Immunologic and Plasma-Dependent Mechanisms of Chronic Hemolysis and Hyperhemolysis in Sickle Cell Disease.

Blood·2026

A new reporter strategy reveals a subset of nonmigratory hematopoietic stem cells located in a dynamic bone marrow niche.

Blood·2026

A randomized phase 2 study combining midostaurin, low-dose cytarabine and venetoclax in newly diagnosed AML ≥60 years.

Blood·2026

Cases of High-Titer Inhibitor Formation After AAV Gene Therapy for Hemophilia A.

Blood·2026

Distribution of Donor Types and Time to Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia Across Ethnic Groups: A Retrospective Study.

Clinical transplantation·2026

Clot Out, Flow Back: Large-Bore Aspiration Thrombectomy for Symptomatic Early Transjugular Intrahepatic Portosystemic Shunt (TIPS) Occlusion.

Cureus·2026

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage.

Cureus·2026

Factor H polymorphism elevates granzyme B and impairs complement inhibition in human and mouse models.

iScience·2026

Breaking the Storm: Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome as the First Manifestation of Systemic Lupus Erythematosus/Mixed Connective Tissue Disease in an Adolescent Successfully Treated With Anakinra.

Cureus·2026

Concizumab for the management of heavy menstrual bleeding in a woman with mild hemophilia A.

Research and practice in thrombosis and haemostasis·2026

Related Experiment Videos

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic

Related Concept Videos

Mutation of hydrophobic residues in the factor Va C1 and C2 domains blocks membrane-dependent prothrombin activation.

Soluble phosphatidylserine binds to a single identified site in the C2 domain of human factor Va.

Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding.

Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues.

Hemophilic factor VIII C1- and C2-domain missense mutations and their modeling to the 1.5-angstrom human C2-domain crystal structure.

Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis.

CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist.

Thrombin-mediated AutoRegulation of FVIII-mimetic antibodies enabling dynamic control of the hemostatic response.

Immunologic and Plasma-Dependent Mechanisms of Chronic Hemolysis and Hyperhemolysis in Sickle Cell Disease.

A new reporter strategy reveals a subset of nonmigratory hematopoietic stem cells located in a dynamic bone marrow niche.

A randomized phase 2 study combining midostaurin, low-dose cytarabine and venetoclax in newly diagnosed AML ≥60 years.

Cases of High-Titer Inhibitor Formation After AAV Gene Therapy for Hemophilia A.

Distribution of Donor Types and Time to Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia Across Ethnic Groups: A Retrospective Study.

Clot Out, Flow Back: Large-Bore Aspiration Thrombectomy for Symptomatic Early Transjugular Intrahepatic Portosystemic Shunt (TIPS) Occlusion.

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage.

Factor H polymorphism elevates granzyme B and impairs complement inhibition in human and mouse models.

Breaking the Storm: Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome as the First Manifestation of Systemic Lupus Erythematosus/Mixed Connective Tissue Disease in an Adolescent Successfully Treated With Anakinra.

Concizumab for the management of heavy menstrual bleeding in a woman with mild hemophilia A.

Related Experiment Videos

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic...

Related Concept Videos

Related Articles

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic