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Acute generalized exanthematous pustulosis: a rare side effect of clindamycin

Sijan Basnet1, Rashmi Dhital1, Biswaraj Tharu2

  • 1Department of Medicine, Reading Hospital, West Reading, PA, USA.

Journal of Community Hospital Internal Medicine Perspectives
|July 2, 2019
PubMed

Insights

Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction to clindamycin. This case highlights a patient whose AGEP rash resolved within a month after discontinuing the antibiotic.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Acute generalized exanthematous pustulosis (AGEP) is a rare but severe cutaneous adverse drug reaction.
  • Clindamycin is an antibiotic that can trigger AGEP, typically presenting 1-3 weeks after initiation.
  • The condition is characterized by widespread non-follicular pustules on an erythematous background.

Purpose of the Study:

  • To report a case of AGEP induced by clindamycin in a patient with a tooth infection.
  • To describe the clinical presentation, management, and outcome of this rare adverse drug reaction.

Main Methods:

  • A case study of a 71-year-old woman is presented.
  • The patient developed a rash after clindamycin treatment for a dental infection.
  • Clinical presentation, diagnostic workup, and treatment response were documented.

Main Results:

  • The patient presented with a widespread pustular rash consistent with AGEP.
  • Empiric treatment with prednisone provided no benefit.
  • The rash resolved completely within one month of discontinuing clindamycin, with no systemic involvement or abnormal blood work.

Conclusions:

  • Clindamycin can induce AGEP, even in the absence of systemic symptoms.
  • Discontinuation of the offending antibiotic is the primary treatment for AGEP.
  • Prompt recognition and management are crucial for favorable outcomes in AGEP cases.
Keywords:
Acute generalized exanthematous pustulosisclindamycinside effect

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