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Updated: Jan 22, 2026
09:25
ROS Live Cell Imaging During Neuronal Development
Published on: February 9, 2021
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Microvesicles: ROS scavengers and ROS producers.
G Bodega1, M Alique2, L Puebla2
1Departamento de Biomedicina y Biotecnología, Universidad de Alcalá, Alcalá de Henares, Spain.
Journal of Extracellular Vesicles
|July 2, 2019
Summary
Microvesicles and reactive oxygen species (ROS) have a two-way relationship. Oxidative stress impacts microvesicle production, while microvesicles can alter ROS levels inside and outside cells.
Area of Science:
- Cell Biology
- Biochemistry
- Oxidative Stress Research
Background:
- Reactive oxygen species (ROS) play crucial roles in cellular signaling and pathology.
- Microvesicles are small extracellular vesicles involved in intercellular communication.
- The interplay between microvesicles and ROS is increasingly recognized as significant.
Purpose of the Study:
- To review the bidirectional relationship between microvesicles and ROS.
- To elucidate the mechanisms by which microvesicles influence ROS homeostasis.
- To highlight the role of microvesicles' molecular cargo in modulating oxidative stress.
Main Methods:
- Literature review of studies investigating microvesicles and ROS.
- Analysis of direct and indirect effects of microvesicles on ROS.
- Examination of molecular components within microvesicles.
Main Results:
- Microvesicle production and content are modulated by oxidative stress.
- Microvesicles directly scavenge or produce ROS via intrinsic machinery.
- Microvesicles indirectly affect cellular ROS metabolism through cargo delivery and signaling pathway regulation.
- Endothelial microvesicles possess a robust antioxidant system.
Conclusions:
- Microvesicles are key regulators of ROS homeostasis.
- The direct and indirect mechanisms highlight microvesicles' dual role in managing oxidative stress.
- Proteins and miRNAs within microvesicles are critical mediators of ROS modulation.
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