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Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality

Urban Alehagen1, Dick Wågsäter2

  • 1Division of Cardiovascular Medicine, Faculty of Medicine and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.

Biomedical Reports
|July 2, 2019
PubMed

Insights

Genetic variations in the lipoprotein receptor-related protein 1 (LRP1) gene are linked to cardiovascular disease risk. Specific LRP1 genotypes significantly increase mortality risk in elderly women, highlighting potential gender-specific cardiovascular prevention strategies.

Area of Science:

  • Genetics
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) pose a significant health burden.
  • Genetic associations, particularly single nucleotide polymorphisms (SNPs), are implicated in CVDs.
  • Lipoprotein receptor-related protein 1 (LRP1) has been linked to coronary artery disease.

Purpose of the Study:

  • To investigate the association between LRP1 gene genotypes and all-cause and cardiovascular mortality.
  • To explore potential gender-specific differences in this association.

Main Methods:

  • A cohort of 489 elderly community-living individuals was studied.
  • Participants underwent clinical examination, echocardiography, and blood sampling for LRP1 (rs1466535) SNP analysis (T/T, C/T, C/C genotypes).
  • Follow-up was conducted for 6.7 years, recording all-cause and cardiovascular deaths.

Main Results:

  • A total of 116 (24%) all-cause deaths and 75 (15%) cardiovascular deaths occurred.
  • In females, LRP1 T/T or C/T genotypes were associated with a 5.6-fold increased risk of cardiovascular mortality and a 2.8-fold increased risk of all-cause mortality compared to the C/C genotype.
  • No significant genotype-related mortality differences were observed in the male population.

Conclusions:

  • Significant gender differences exist in mortality risk associated with LRP1 genotypes.
  • Females with LRP1 T/T or C/T genotypes face a substantially higher risk of all-cause and cardiovascular mortality.
  • These findings suggest the need for individualized cardiovascular prevention and treatment strategies, though further research is warranted due to the study's small size.

Keywords:
elderlygendersgenotypeslow-density lipoprotein receptor-related protein 1mortality

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