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Updated: Jan 22, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion
Nan-Yu Cheng1, Yi-Ling Lin1, Ming-Chien Fang1
1Department of Photonics, National Cheng Kung University, Tainan, Taiwan.
Abstract:
Transcutaneous bilirubinometers are widely used to screen neonatal jaundice. However, it was reported that their accuracy is compromised at low and high bilirubin levels. We used a photon diffusion theory-based method valid in the 450-600 nm wavelength region to overcome this obstacle. Our clinical study results showed that our system could properly determine the transcutaneous bilirubin concentrations at total serum bilirubin levels higher than 14 mg/dL, where a commercial bilirubinometer failed to provide proper results in several cases. These findings suggested that photon diffusion theory could be employed to improve the core algorithm of modern bilirubinometers and enhance their applicability.
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