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VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

Ronaldo Celerino da Silva1, Neyla Maria Pereira Alves1,2, Jorge José de Souza Pereira1,3

  • 1Laboratorio de Immunopatologyia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, PE, Brazil.

Genetics and Molecular Biology
|July 2, 2019
PubMed

Insights

Vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) may influence treatment outcomes in HIV-1 patients. Specific VDR gene variations might be linked to immunological failure despite antiretroviral therapies (ARVs).

Area of Science:

  • Immunology
  • Genetics
  • Virology

Background:

  • Vitamin D modulates immune cell function via the vitamin D receptor (VDR).
  • Age and protease inhibitor regimens can impact antiretroviral therapy (ART) effectiveness.
  • Immunological failure in HIV-1 patients remains a significant clinical concern.

Purpose of the Study:

  • To investigate the association between VDR single nucleotide polymorphisms (SNPs) and immunological failure in HIV-1-positive individuals.
  • To explore the role of specific VDR SNPs (rs11568820) and their allelic combinations (GC, rs2228570-rs11568820) in treatment outcomes.

Main Methods:

  • Retrospective analysis of HIV-1-positive patients undergoing ART.
  • Genotyping for VDR SNPs, specifically rs11568820 (C allele, CC genotype).
  • Assessment of GC allelic combinations (rs2228570-rs11568820) in relation to immunological failure.

Main Results:

  • A statistically significant association (p < 0.05) was observed between VDR SNPs and immunological failure.
  • The C allele and CC genotype of VDR SNP rs11568820 showed a potential link to treatment failure.
  • Specific GC allelic combinations were also implicated in immunological outcomes.

Conclusions:

  • VDR gene variations, including specific SNPs and allelic combinations, may play a role in determining immunological response to ART in HIV-1 patients.
  • These genetic factors could contribute to treatment variability and immunological failure.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications of VDR SNPs in HIV-1 management.

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