Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse

Junjun Jing1,2, Jifan Feng1, Jingyuan Li1

  • 1Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.

Elife
|July 2, 2019
PubMed
Summary

Epigenetic regulator Ezh2 in dental mesenchyme controls tooth root patterning and furcation formation during development. An Ezh2 and Arid1a interaction regulates Cdkn2a, impacting tooth root development and function.

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