Related Experiment Video

Updated: Jan 22, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.6K

The predictive value of stress hyperglycemia on thrombus burden in nondiabetic patients with ST-segment elevation

Serhat Sigirci1, Süleyman S Yildiz, Kudret Keskin

  • 1Department of Cardiology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|July 2, 2019
PubMed

Insights

Stress hyperglycemia independently predicts large thrombus burden in non-diabetic ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. This finding highlights hyperglycemia

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomedical Research

Background:

  • Hyperglycemia is known to affect platelet function and fibrin structure.
  • Understanding hyperglycemia's role in acute cardiac events is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the predictive value of hyperglycemia for thrombus burden in non-diabetic patients with ST-segment elevation myocardial infarction (STEMI).
  • To assess the association between stress hyperglycemia and large thrombus burden (LTB) in patients undergoing primary percutaneous coronary intervention (PPCI).

Main Methods:

  • A cohort of 619 non-diabetic STEMI patients undergoing PPCI was analyzed.
  • Patients were categorized based on thrombus burden (grades 4 as LTB) and stress hyperglycemia (blood glucose >180 mg/dL).
  • Multivariate logistic regression was used to identify independent predictors of LTB.

Main Results:

  • 11.0% of patients experienced stress hyperglycemia, and 36.0% had LTB.
  • Patients with LTB had significantly higher admission blood glucose levels compared to those with small thrombus burden (145.9 ± 43.1 mg/dL vs. 135 ± 39.1 mg/dL, P=0.002).
  • Stress hyperglycemia was identified as an independent predictor of LTB (OR: 3.025, P=0.019).

Conclusions:

  • Admission hyperglycemia is significantly associated with large thrombus burden in STEMI patients.
  • Hyperglycemia may play a critical role in the development of coronary thrombus.
  • These findings suggest hyperglycemia as a potential therapeutic target to improve outcomes in STEMI.

More Related Videos

Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.7K

Related Concept Videos

Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
39.6K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
45.5K
Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
280
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.3K
Responses to Salt Stress02:02

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
End Point Prediction: Gran Plot01:07

End Point Prediction: Gran Plot

A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
1.2K