Related Experiment Video
Updated: Jan 22, 2026

Measuring Diffusion Coefficients via Two-photon Fluorescence Recovery After Photobleaching
Published on: February 26, 2010
A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma
Sameer Farouk Sait1,2, Sofia Haque3,4, Sasan Karimi3,4
1Departments of Pediatrics.
Abstract:
We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures.
Related Concept Videos
Role of Communication in the Nursing Process I: Assessment and Diagnosis
The nursing process considers the patient's emotional and physical well-being. The process can be repeated or stopped at any point if judged essential. Assessment is the first step in the nursing...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Apparent Weight
Consider a person standing on a bathroom scale inside an elevator. If the scale is accurate at rest, its reading equals the...
Diffusion
Apparent Weight and the Earth's Rotation
For an object on the Earth's equator, the net centripetal force that accounts for its rotation is the Earth's pull towards its center, or the weight minus the normal force that prevents it from piercing into the Earth's surface....
Coefficient of Correlation
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...

