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Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and

Mal-Soon Shin1, Tae-Won Kim2, Sang-Seo Park2

  • 1School of Global Sport Studies, Korea University, Sejong, Korea.

International Neurourology Journal
|July 2, 2019
PubMed
Abstract

Insights

Surgical and chemical castration in rats impaired memory and reduced neurogenesis. These effects were linked to decreased activity in the PKA/CREB/BDNF and c-Raf/MEK/ERK signaling pathways in the hippocampus.

Area of Science:

  • Neuroscience
  • Endocrinology

Background:

  • Goserelin is a drug used for chemical castration.
  • Castration can impact various physiological functions, including cognitive processes.

Purpose of the Study:

  • Investigate the effects of surgical (orchiectomy) and chemical (goserelin) castration on memory in a rat model.
  • Examine the involvement of the PKA/CREB/BDNF and c-Raf/MEK/ERK signaling pathways in the hippocampus.

Main Methods:

  • Surgical castration via orchiectomy and chemical castration using goserelin acetate.
  • Immunohistochemistry to quantify neurogenesis and Western blotting to assess protein pathway phosphorylation.

Main Results:

  • Both orchiectomy and goserelin groups exhibited reduced neurogenesis and impaired short-term and spatial memory.
  • Decreased phosphorylation of PKA/CREB/BDNF and c-Raf/MEK/ERK signaling pathways was observed in both castration groups.

Conclusions:

  • Surgical and chemical castration negatively affect short-term and spatial memory.
  • These memory deficits are mediated through the PKA/CREB/BDNF and c-Raf/MEK/ERK signaling pathways in the hippocampus.
Keywords:
CastrationMemoryNeurogenesis

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