Microbiota-gut brain axis involvement in neuropsychiatric disorders.

Area of Science:

• Neuroscience
• Microbiology
• Psychiatry

Background:

• The microbiota-gut brain (MGB) axis describes bidirectional communication between gut microbes and the brain.
• Growing evidence links the gut microbiome to neuropsychiatric health.
• Further research is needed to understand gene-environment interactions and MGB axis roles in neuropsychiatric diseases.

Purpose of the Study:

• To review the MGB axis's role in neuropsychiatric disorders.
• To explore disease prediction and prevention using microbiome and '-Omics' data.
• To evaluate technological advances for investigating and modulating the gut microbiota.

Main Methods:

• Literature review focusing on MGB axis and neuropsychiatric disorders.
• Integration of gut microbiome/microbiota data with international '-Omics' studies.
• Evaluation of current technologies for microbiome investigation and modulation.

Main Results:

• Clinical studies show associations between altered gut microbiota and neuropsychiatric conditions.
• Preclinical studies demonstrate the gut microbiota's impact on behaviors relevant to CNS disorders.
• The MGB axis is implicated in the pathophysiology of various neuropsychiatric conditions.

Conclusions:

• Targeting the MGB axis presents a novel therapeutic strategy for CNS disorders.
• Modulating the gut microbiota could be beneficial for conditions involving microbial alterations.
• Understanding the MGB axis is crucial for developing biomarkers and improving treatments for neuropsychiatric diseases.