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Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic beta-cells
T Nilsson1, J Zwiller, A L Boynton
1Department of Medical Cell Biology, University of Uppsala, Sweden.
FEBS Letters
|February 29, 1988
Abstract:
Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic beta-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.