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Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity

Ola A Abdelaziz1, Walaa M El Husseiny1, Khalid B Selim1

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Bioorganic Chemistry
|July 2, 2019
PubMed

Keywords:
Antitumor activityApoptosisCell cycle arrestDHFR inhibitorPyrido[2,3-d]pyrimidine

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