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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
Nanostructured lipid carriers loaded with free phytosterols for food applications
Valeria da Silva Santos1, Bruno Brito Braz1, Alan Ávila Silva2
1Department of Biotechnological Processes, School of Chemical Engineering, University of Campinas, 500 Albert Einstein Ave., Campinas, SP 13083-970, Brazil.
Abstract:
The objective of this study was to develop nanostructured lipid carriers (NLCs) with free phytosterols (FP) using conventional fats and oils. Lipid matrices (LMs) and NLCs were produced with high oleic sunflower oil, fully hydrogenated canola (CA) and crambe (CR) oils by high-pressure homogenization (HPH). The NLCs were evaluated for hydrodynamic diameter (Z-ave), polydispersity index (PDI), and zeta potential (ZP). The melting behavior and polymorphism were investigated for both, the LMs and NLCs. The NLCs presented particle sizes ranging from 148.23 to 342.10 nm, PDI from 0.275 to 0.481, and ZP between -22.27 and -29.70 mV. The NLCs presented higher thermal resistance than that of the LMs. The use of CA and CR separately in the NLC formulations favored the incorporation of FP. The LMs and NLCs presented crystals in β-form and in mixtures of β' and β forms. The developed NLCs can be used for food enrichment, such as spreads, margarine, and beverages.
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