Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

24
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
24

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cervical Injury Outcomes among Older Adults Admitted to an Inpatient Trauma Service.

The journal of nutrition, health & aging·2021
Same author

Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1.

Journal of dental research·2014
Same author

Levetiracetam in patients with central neuropathic post-stroke pain--a randomized, double-blind, placebo-controlled trial.

European journal of neurology·2012
Same author

Intracisternal injection of inflammatory soup activates the trigeminal nerve system.

Cephalalgia : an international journal of headache·2009
Same author

Health-related quality of life measures and psychiatric comorbidity in patients with migraine.

European journal of neurology·2009
Same author

Environmental hazards and stress: evidence from the Texas City Stress and Health Study.

Journal of epidemiology and community health·2009
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
14:15

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Published on: June 18, 2012

25.7K

Suppressor cell function in sarcoidosis.

J S Goodwin, R DeHoratius, H Israel

    Annals of Internal Medicine
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Suppressor cells and increased monocytes impair cellular immunity in sarcoidosis patients, reducing phytohemagglutinin responses. Modulating these factors may restore immune function in sarcoidosis.

    More Related Videos

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
    07:17

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

    Published on: June 22, 2016

    9.5K
    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
    08:41

    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

    Published on: June 7, 2017

    7.5K

    Related Experiment Videos

    Last Updated: May 3, 2026

    Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
    14:15

    Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

    Published on: June 18, 2012

    25.7K
    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
    07:17

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

    Published on: June 22, 2016

    9.5K
    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
    08:41

    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

    Published on: June 7, 2017

    7.5K

    Area of Science:

    • Immunology
    • Cellular Immunity
    • Sarcoidosis Research

    Background:

    • Patients with sarcoidosis exhibit depressed cellular immunity.
    • Suppressor cells are implicated in immune dysfunction in sarcoidosis.

    Purpose of the Study:

    • To investigate the role of suppressor cells in the depressed cellular immunity observed in sarcoidosis patients.
    • To identify factors contributing to impaired immune responses in sarcoidosis.

    Main Methods:

    • Assessed phytohemagglutinin (PHA) response in sarcoidosis patients and controls.
    • Utilized glass wool filtration to isolate cell populations.
    • Measured PHA response after indomethacin addition to cultures.
    • Correlated monocyte percentages with immune response changes.

    Main Results:

    • Sarcoidosis patients showed significantly lower PHA responses compared to controls.
    • Glass wool passage increased PHA response in patients by 116%, but decreased it in controls.
    • Indomethacin significantly enhanced PHA response in sarcoidosis patients.
    • Increased monocyte percentage in sarcoidosis patients correlated with improved PHA response after cell separation.

    Conclusions:

    • Prostaglandin-producing suppressor cells contribute to impaired cellular immunity in sarcoidosis.
    • Elevated monocyte counts and an unidentified factor also play a role in the depressed PHA response.
    • Findings suggest a multifactorial basis for immune dysfunction in sarcoidosis.