Serum osteocalcin levels in overweight children
Seok Bin Oh1, Won Young Lee1, Hyo-Kyoung Nam1
1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
Annals of Pediatric Endocrinology & Metabolism
|July 2, 2019
Summary
Serum osteocalcin levels are lower in overweight children and correlate with poorer glucose metabolism and insulin sensitivity. These findings suggest a link between bone health and metabolic regulation in pediatric obesity.
Area of Science:
- Endocrinology
- Pediatric Metabolism
- Bone Biology
Background:
- Osteocalcin, a bone-derived hormone, influences glucose metabolism.
- It impacts insulin secretion, sensitivity, and energy expenditure.
- Understanding osteocalcin's role in pediatric obesity is crucial.
Purpose of the Study:
- To measure serum osteocalcin levels in overweight children.
- To investigate associations between osteocalcin, glucose metabolism, and insulin sensitivity.
Main Methods:
- Serum osteocalcin, glucose, insulin, and lipid profiles were measured in overweight (n=50) and control (n=60) children.
- Anthropometric measurements including BMI and SDS were recorded.
- Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated.
Main Results:
- Overweight children had significantly lower serum osteocalcin levels than controls (P<0.001).
- Osteocalcin inversely correlated with BMI, weight SDS, BMI SDS, insulin, and HOMA-IR (P<0.005).
- BMI, HOMA-IR, and age were independent predictors of serum osteocalcin.
Conclusions:
- Serum osteocalcin is associated with glucose metabolism and insulin sensitivity in overweight children.
- While associations exist, a causal relationship could not be established.
- Further research is needed to elucidate the role of osteocalcin in pediatric metabolic health.
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