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Thyroid function in girls with central precocious puberty.

Geehae Jung1, Seok-Bin Oh1, Won Young Lee1

  • 1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

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|July 2, 2019
PubMed
Summary
This summary is machine-generated.

Girls with central precocious puberty (CPP) show higher thyroid stimulating hormone (TSH) levels and a greater prevalence of hyperthyrotropinemia. Pubertal onset, indicated by luteinizing hormone (LH) elevation, is linked to altered thyroid function in these cases.

Keywords:
ObesityThyroid hormonePrecocious puberty

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Endocrinology
  • Thyroidology

Background:

  • Obesity is a known risk factor for central precocious puberty (CPP).
  • Elevated thyroid stimulating hormone (TSH) has been observed in obese youth.
  • Limited data exist on the relationship between CPP and TSH levels.

Purpose of the Study:

  • To evaluate thyroid function in girls diagnosed with CPP.
  • To investigate the association between CPP and serum TSH concentration.

Main Methods:

  • Retrospective cross-sectional study of 1,247 girls (aged 6.0-8.9 years).
  • Subjects categorized into CPP (n=554) and non-CPP (n=693) groups based on gonadotropin-releasing hormone (GnRH) stimulation test results.
  • Comparison of characteristics and laboratory data, including TSH and free thyroxine (fT4), between groups.

Main Results:

  • Girls with CPP exhibited higher serum TSH concentrations (3.19±1.55 mIU/L vs. 2.58±1.34 mIU/L) and lower serum fT4 concentrations (1.38±0.14 ng/dL vs. 1.44±0.18 ng/dL) compared to the non-CPP group.
  • The prevalence of hyperthyrotropinemia was significantly higher in the CPP group (15.7% vs. 8.9%).
  • TSH levels positively correlated with age, BMI, bone age, IGF-1, and pubertal hormones (LH, FSH); negatively correlated with fT4. Age and peak LH were independent predictors of TSH.

Conclusions:

  • Hyperthyrotropinemia in girls with CPP is associated with pubertal LH elevation.
  • The onset of puberty may be linked to alterations in thyroid function.