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Updated: Jan 22, 2026

Induction of Retinal Ischemia-Reperfusion Injury in a Mouse Eye Model
Published on: December 20, 2024
A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion
Hiromitsu Kunimi1,2, Yukihiro Miwa1,2, Hiroyoshi Inoue3
1Department of Ophthalmology, School of Medicine, Keio University, Shinjuku-ku, 160-8582 Tokyo, Japan.
Abstract:
Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis and revealed that HIF inhibition may be effective against retinal neovascular and neurodegeneration. In this study, we performed in vitro screening of natural products and found halofuginone, which is a derivative of febrifugine extracted from hydrangea, as a novel HIF inhibitor. Administration of halofuginone showed a significant neuroprotective effect by inhibiting HIF-1α expression in a murine retinal ischemia-reperfusion model histologically and functionally. These results indicate that halofuginone can be a neuroprotective agent in ischemic retinal degenerative diseases.
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