Related Experiment Video

Updated: Jan 22, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.8K

Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic Inflammation

Sandra Romero-Cordoba1,2, Elisabetta Meneghini3, Milena Sant3

  • 1Biochemistry Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.

Cancers
|July 3, 2019
PubMed

Insights

Systemic inflammation markers, like the platelet-to-lymphocyte ratio (PLR), can reliably indicate the local immune microenvironment in triple-negative breast cancer (TNBC). This finding aids in understanding tumor characteristics and selecting optimal therapies for TNBC patients.

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Triple-negative breast cancer (TNBC) is aggressive with limited treatment options.
  • Immune profiles significantly influence chemotherapy and immunotherapy effectiveness.
  • A deeper understanding of the immune infiltrate landscape and biomarkers is crucial for advancing TNBC immuno-oncology.

Purpose of the Study:

  • To identify distinct immune features within TNBC subtypes.
  • To explore the relationship between systemic inflammation markers and the local tumor immune microenvironment.
  • To determine the utility of easily detectable biomarkers for TNBC patient stratification.

Main Methods:

  • Analysis of gene expression profiles from 54 TNBC cases.
  • Molecular characterization of immune cell cytolytic activity and tumor inflammation.
  • Evaluation of platelet-to-lymphocyte ratio (PLR) from pre-surgical blood tests.
  • Correlation analysis between PLR, immune activity, and tumor aggressiveness.

Main Results:

  • Three TNBC clusters with unique immune characteristics were identified.
  • Variability in local immune infiltrate composition was observed across clusters.
  • PLR was negatively correlated with local immune cytolytic activity and T cell-inflamed microenvironment.
  • Tumor aggressiveness positively correlated with PLR values.

Conclusions:

  • Systemic inflammation parameters, such as PLR, serve as reliable indicators of the local immune tumor microenvironment in TNBC.
  • These markers can help decipher tumor infiltrate properties.
  • Exploiting systemic inflammation markers may lead to improved patient selection for targeted therapies in TNBC.
Keywords:
CBCPLRTILsTNBCimmune heterogeneityinflammationplatelet

More Related Videos

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.0K
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.6K

Related Concept Videos

Inflammation01:38

Inflammation

Overview
61.8K
Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
814
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.4K
What is the Immune System?01:38

What is the Immune System?

Overview
127.1K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.1K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K