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How to Modify Drug Release in Paediatric Dosage Forms? Novel Technologies and Modern Approaches with Regard to
Monika Trofimiuk1,2, Katarzyna Wasilewska1, Katarzyna Winnicka3
1Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Insights
Developing modified release (MR) drug dosage forms for children is crucial. This article explores strategies for paediatric modified release oral formulations to improve treatment personalization and adherence.
Area of Science:
- Pharmaceutical Technology
- Paediatric Drug Delivery
Background:
- Paediatric populations present unique challenges in drug formulation development.
- Off-label use of adult formulations is common due to a lack of age-appropriate paediatric dosage forms.
- Children require personalized treatments and patient-friendly preparations, often necessitating modified release (MR) forms.
Purpose of the Study:
- To explore methods for modifying drug release in paediatric oral dosage forms.
- To discuss existing technologies for paediatric modified release formulations.
- To introduce novel manufacturing approaches for paediatric MR dosage forms.
Main Methods:
- Review of current pharmaceutical technologies for drug release modification.
- Analysis of accessible manufacturing techniques for paediatric formulations.
- Exploration of innovative approaches in paediatric drug delivery.
Main Results:
- Modified release (MR) formulations are underutilized in paediatric therapy compared to adult use.
- Significant challenges exist in developing flexible and appropriate drug dosage forms for children.
- Personalized and patient-friendly MR dosage forms can improve paediatric treatment and reduce dosing frequency.
Conclusions:
- Tailoring drug release is essential for effective paediatric oral dosage forms.
- Accessible and novel manufacturing technologies are needed to meet paediatric needs for MR formulations.
- Addressing the lack of paediatric-specific MR forms can enhance therapeutic outcomes and patient compliance.
Abstract:
In the pharmaceutical technology, paediatric population still presents the greatest challenge in terms of developing flexible and appropriate drug dosage forms. As for many medicines, there is a lack of paediatric dosage forms adequate for a child's age; it is a prevailing practice to use off label formulations. Children need balanced and personalized treatment, patient-friendly preparations, as well as therapy that facilitates dosing and thus eliminates frequent drug administration, which can be ensured by modified release (MR) forms. MR formulations are commonly used in adult therapy, while rarely available for children. The aim of this article is to elucidate how to modify drug release in paediatric oral dosage forms, discuss the already accessible technologies and to introduce novel approaches of manufacturing with regard to paediatric population.