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Updated: Jan 22, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
Published on: March 9, 2019
One Step Preparation of Peptide-Coated Gold Nanoparticles with Tunable Size
Yongmei Jia1, Xiaoning Yan1, Xin Guo1
1Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, School of Chemistry and Chemical Engineering, Lingnan Normal University, Cunjin Road, Zhanjiang 524048, China.
Abstract:
Gold nanoparticles (AuNPs) made from self-assembling peptides have been used in many research fields and attracted a great deal of attention due to their high stability, biocompatibility and functionality. However, existing preparation methods for peptide-coated AuNPs are post-synthesis processes, which are complicated and time consuming. Therefore, a one-step preparation method for peptide-coated AuNPs is proposed here. The AuNPs obtained by this method exhibit good stability. Importantly, peptide-coated AuNPs with precise different sizes can be prepared by this method through pH control of reducing reagent tyrosine in range of 10.0~12.7. Thus, the one-step preparation method proposed here provides a significant tool for the research in different fields concerning NP size, stability and biocompatibility.
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