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Updated: Jun 12, 2026
08:43
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Inflammatory Bowel Disease: A Stressed "Gut/Feeling".
Yvonne Oligschlaeger1, Tulasi Yadati1, Tom Houben1
1School of Nutrition & Translational Research in Metabolism (NUTRIM), Department of Molecular Genetics, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Cells
|July 3, 2019
Summary
Stress significantly impacts inflammatory bowel disease (IBD) by disrupting the gut-brain axis. Managing stress is crucial for IBD remission and preventing disease progression.
Area of Science:
- Gastroenterology
- Neuroscience
- Immunology
Background:
- Inflammatory bowel disease (IBD) is a chronic condition characterized by gut-brain axis dysregulation.
- The gut-brain axis involves complex communication pathways including the nervous system, immune system, and gut microbiota.
- Stress is increasingly recognized as a factor influencing IBD activity and relapse.
Purpose of the Study:
- To review the interplay between the gut microbiota, brain, and chronic gastrointestinal inflammation in IBD.
- To elucidate the specific role of stress in modulating the gut-brain axis in IBD.
- To evaluate the therapeutic potential of stress management strategies for IBD.
Main Methods:
- Literature review focusing on the gut-brain axis in IBD.
- Analysis of studies investigating the impact of stress on intestinal inflammation and permeability.
- Evaluation of research on stress management interventions in IBD patients.
Main Results:
- Stress negatively affects the gut-brain axis, altering intestinal permeability and cytokine profiles.
- These alterations induced by stress can exacerbate IBD relapse risk and disease severity.
- Evidence suggests stress management interventions may offer therapeutic benefits in IBD.
Conclusions:
- The gut-brain-microbiota axis is central to IBD pathogenesis.
- Stress is a significant environmental factor contributing to IBD exacerbations.
- Stress management represents a promising complementary therapeutic approach for IBD management.
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