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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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Related Experiment Video

Updated: Jun 12, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

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Published on: February 1, 2012

Inflammatory Bowel Disease: A Stressed "Gut/Feeling".

Yvonne Oligschlaeger1, Tulasi Yadati1, Tom Houben1

  • 1School of Nutrition & Translational Research in Metabolism (NUTRIM), Department of Molecular Genetics, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

Cells
|July 3, 2019
PubMed
Summary

Stress significantly impacts inflammatory bowel disease (IBD) by disrupting the gut-brain axis. Managing stress is crucial for IBD remission and preventing disease progression.

Keywords:
IBDbraingastrointestinal tractinterplaymicrobiotastress

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Immunology

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition characterized by gut-brain axis dysregulation.
  • The gut-brain axis involves complex communication pathways including the nervous system, immune system, and gut microbiota.
  • Stress is increasingly recognized as a factor influencing IBD activity and relapse.

Purpose of the Study:

  • To review the interplay between the gut microbiota, brain, and chronic gastrointestinal inflammation in IBD.
  • To elucidate the specific role of stress in modulating the gut-brain axis in IBD.
  • To evaluate the therapeutic potential of stress management strategies for IBD.

Main Methods:

  • Literature review focusing on the gut-brain axis in IBD.
  • Analysis of studies investigating the impact of stress on intestinal inflammation and permeability.
  • Evaluation of research on stress management interventions in IBD patients.

Main Results:

  • Stress negatively affects the gut-brain axis, altering intestinal permeability and cytokine profiles.
  • These alterations induced by stress can exacerbate IBD relapse risk and disease severity.
  • Evidence suggests stress management interventions may offer therapeutic benefits in IBD.

Conclusions:

  • The gut-brain-microbiota axis is central to IBD pathogenesis.
  • Stress is a significant environmental factor contributing to IBD exacerbations.
  • Stress management represents a promising complementary therapeutic approach for IBD management.