Related Experiment Video

Updated: Jan 22, 2026

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases
06:56

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases

Published on: September 6, 2024

809

Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential

Tomasz Kostrzewa1, Joanna Styszko1, Magdalena Gorska-Ponikowska1

  • 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.

Anticancer Research
|July 3, 2019
PubMed
Abstract

Insights

Protein tyrosine phosphatase 1B (PTP1B) inhibitors show promise as anticancer treatments. This review highlights PTP1B inhibitors and current research trends for cancer therapy.

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Protein tyrosine phosphatase 1B (PTP1B) is implicated in the pathogenesis of various cancers, including breast and lung cancer.
  • PTP1B's role in oncogenic transformation makes it a significant target for novel anticancer strategies.

Purpose of the Study:

  • To review existing studies on PTP1B inhibitors as potential therapeutic agents.
  • To outline current research trends in the development of PTP1B-targeted cancer therapies.

Main Methods:

  • Literature review conducted using the PubMed database.
  • Analysis of relevant research studies, including internal departmental findings.

Main Results:

  • PTP1B is a validated and promising drug target due to its involvement in cancer development.
  • Selected PTP1B inhibitors have demonstrated efficacy in preclinical and clinical studies.

Conclusions:

  • Effective PTP1B inhibitors represent a promising avenue for anticancer treatment.
  • These inhibitors may be utilized as monotherapy or in combination with existing anticancer drugs.
Keywords:
PTP1B phosphataseanticancer compoundsreviewtyrosine phosphatase's inhibitors

More Related Videos

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

18.6K
Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.6K

Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.0K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

4.4K
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
464
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
18.2K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
10.9K
The Resting Membrane Potential01:21

The Resting Membrane Potential

Overview
142.0K