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Updated: Jan 22, 2026

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Published on: April 10, 2020
Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment
Judyta Zabielska1, Tomasz Sledzinski2, Ewa Stelmanska1
1Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Abstract:
Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of proliferation in a range of cancer cell types both in vitro and in vivo. The exact mechanism of this phenomenon is being investigated, and the most important findings are presented in this review.
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