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Translational Orthotopic Models of Glioblastoma Multiforme
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Translational Orthotopic Models of Glioblastoma Multiforme

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Pleiotropic Chemotherapy to Abrogate Glioblastoma Multiforme Migration/Invasion

Lawrence Helson1, Muhammed Majeed2

  • 1Consultant, Sabinsa Corporation, East Windsor, NJ, U.S.A. lhelson@comcast.net.

Anticancer Research
|July 3, 2019
PubMed

Insights

Glioblastoma multiforme (GBM) treatment fails due to tumor complexity and spread. Withaferin A may offer a new therapeutic strategy by targeting GBM cell invasion and proliferation.

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Primary glioblastoma multiforme (GBM) remains largely incurable in adult patients.
  • Treatment failures stem from genetic aberrations, molecular heterogeneity, and clonal evolution within GBM.
  • These factors contribute to drug resistance, incomplete surgical resection, and ineffective radiotherapy.

Purpose of the Study:

  • To explore Withaferin A as a potential therapeutic agent for glioblastoma multiforme.
  • To investigate the efficacy of Withaferin A, alone or in combination, in addressing GBM's aggressive characteristics.

Main Methods:

  • The study focuses on the molecular mechanisms underlying GBM progression, including cell motility, migration, and invasion.
  • It proposes the use of Withaferin A and pleiotropic drugs to counteract these mechanisms.

Main Results:

  • Withaferin A and combination therapies show promise in targeting pathways that promote tumor cell motility, migration, invasion, and proliferation.
  • These agents may overcome key challenges leading to current clinical treatment failures.

Conclusions:

  • Withaferin A presents a potential therapeutic avenue for glioblastoma multiforme.
  • Combination therapies targeting aberrant molecules and pathways could improve treatment outcomes for GBM.
Keywords:
Glioblastoma multiformeinvasionmigrationmotilitypleiotropic drugsproliferationreviewwithaferin A

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