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Updated: Jan 22, 2026

Assessing Specificity of Anticancer Drugs In Vitro
Published on: March 23, 2016
In Vitro Anticancer Activities of B6 Vitamers: A Mini-review
Taisuke Matsuo1, Yasuyuki Sadzuka2
1Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University, Iwate, Japan tmatsuo@iwate-med.ac.jp.
Abstract:
Vitamin B6 compounds, including pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated forms, have been investigated with regard to their cancer preventive and therapeutic effects through epidemiological, in vivo, and in vitro studies. In particular, in vitro studies in cancer cells have evaluated the effects of several B6 vitamers such as pyridoxine, pyridoxal, pyridoxamine, and pyridoxal-5'-phosphate, which is a bioactive form of vitamin B6 However, the anticancer activity and concentration required to influence cancer cells vary among B6 vitamers. In this review, the various in vitro effects of vitamin B6 compounds on cancer cells are presented and discussed.
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