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Area of Science:

  • Oncology
  • Pathology
  • Biobanking

Background:

  • Rapid autopsy enables procurement of diverse cancer tissues.
  • Unexplored avenues in cancer research can be opened through post-mortem tissue acquisition.
  • A high-volume rapid research autopsy program was established at an academic medical center.

Purpose of the Study:

  • To describe a high-volume rapid research autopsy program.
  • To acquire multidimensionally annotated tissue for cancer research.
  • To enable studies in tumor immunology, xenografts, genomics, and proteomics.

Main Methods:

  • Patients with advanced-stage cancer were approached for consent.
  • A notification plan was enacted upon patient death.
  • Tissues were annotated in a bioinformatics database and linked to electronic patient records.
  • Tumor integrity, including DNA and RNA quality, was assessed.

Main Results:

  • Over 100 rapid research autopsies were performed.
  • Diverse cancer site specimens were procured and annotated with clinical information.
  • Procured tissues facilitated studies in tumor immunology, xenografts, genomics, and proteomics.

Conclusions:

  • Large-scale rapid procurement and biobanking of cancer tissues is feasible.
  • Multidisciplinary integration is critical for program success.
  • This program provides valuable resources for cancer research.