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Role of sepsis modulated circulating microRNAs

Bernadett Szilágyi1, Zsolt Fejes1, Marianna Pócsi1

  • 1Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Hungary.

EJIFCC
|July 3, 2019
PubMed

Insights

Altered microRNA (miRNA) expression impacts sepsis development and outcomes. Circulating miRNAs show promise as diagnostic and prognostic biomarkers for sepsis, reflecting Toll-like receptor (TLR) signaling pathways.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Sepsis involves a dysregulated host response to infection, potentially leading to multi-organ failure.
  • Current sepsis biomarkers have limitations in severe clinical settings.
  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression and intracellular events, including Toll-like receptor (TLR) signaling.

Purpose of the Study:

  • To review the role of miRNAs in TLR-mediated inflammatory signaling in sepsis.
  • To explore the potential of circulating miRNAs as diagnostic and prognostic biomarkers for sepsis.

Main Methods:

  • Literature review of clinical studies on miRNA expression in sepsis.
  • Analysis of miRNA regulation in immune cells and platelets during sepsis.
  • Examination of TLR signaling pathways and their miRNA-dependent control.

Main Results:

  • Abnormal miRNA expression is linked to sepsis development, clinical features, and outcomes.
  • Altered levels of circulating miRNAs correlate with sepsis severity and prognosis.
  • miRNAs modulate intracellular responses in immune cells and platelets during sepsis.

Conclusions:

  • Circulating miRNAs represent promising biomarkers for sepsis diagnosis and prognosis.
  • Understanding miRNA regulation of TLR pathways is crucial for sepsis management.
  • Further research into miRNAs could lead to novel therapeutic strategies for sepsis.
Keywords:
TLRinflammationmicroRNAmonocyteplateletsepsis

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