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Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study

Chengbo Liu1, Yan Chen1,2, Dongying Zhao1

  • 1Department of Neonatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Frontiers in Neurology
|July 3, 2019
PubMed

Insights

Funisitis, an inflammation of the umbilical cord, is linked to lower childhood IQ scores in preterm infants at age 4. This effect on performance IQ persists until age 7 in term infants.

Area of Science:

  • Neonatal neurology
  • Developmental pediatrics
  • Obstetrics

Background:

  • Prenatal inflammation is a suspected cause of brain injury in preterm infants.
  • The impact of funisitis on childhood neurodevelopment requires further investigation.

Purpose of the Study:

  • To examine the association between funisitis and childhood intelligence quotient (IQ).
  • To test the hypothesis that childhood neurodevelopment differs between infants with and without funisitis.

Main Methods:

  • Utilized data from 29,725 subjects in the U.S. Collaborative Perinatal Project (1959-1976).
  • Conducted detailed placental examinations and applied multivariate logistic regression.
  • Assessed the relationship between funisitis and IQ at ages 4 and 7, adjusting for confounders.

Main Results:

  • Children born early preterm with funisitis showed a 3.0-fold increased risk of low full-scale IQ (<70) at age 4, which resolved by age 7.
  • Term-born children with funisitis had a 1.9-fold increased risk of low performance IQ at age 7, but not low full-scale IQ.
  • No significant IQ differences were observed in late preterm infants.

Conclusions:

  • Funisitis may negatively impact infant brain development, leading to lower IQ at age 4.
  • The detrimental effect of funisitis appears limited to performance IQ at age 7 in term-born infants.

Keywords:
fetal inflammatory response syndromeintelligence quotientintrauterine infectionpretermterm

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