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Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Seshadri Balaji1, Michael P DiLorenzo2, Frank A Fish3

  • 1Division of Cardiology, Department of Pediatrics, Oregon Health & Science University, 707, SW Gaines Street, Mailcode: CDRC-P, Portland, OR, 97239, USA. balajis@ohsu.edu.

Pediatric Cardiology
|July 3, 2019
PubMed

Insights

Obesity is linked to increased posterior wall thickness (PWT) in children with hypertrophic cardiomyopathy (HCM), but not interventricular septal thickness (IVST). Further research is needed to understand obesity's impact on clinical outcomes in pediatric HCM.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Obesity Research

Background:

  • Obesity is a known contributor to left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM).
  • The impact of obesity on LVH in pediatric HCM patients remains under-investigated.
  • Understanding these associations is crucial for managing pediatric cardiovascular health.

Purpose of the Study:

  • To investigate the association between obesity and left ventricular hypertrophy (LVH) in children diagnosed with hypertrophic cardiomyopathy (HCM).
  • To determine if obesity influences specific echocardiographic measures of LVH, namely interventricular septal thickness (IVST) and posterior wall thickness (PWT), in pediatric HCM patients.

Main Methods:

  • Echocardiographic measurements of LV dimensions, including IVST and PWT, were collected from 504 children with HCM.
  • Patient weight and height were recorded to calculate Body Mass Index (BMI).
  • Obesity was defined as BMI ≥ 99th percentile for age and sex; statistical analyses were performed to assess associations with IVST and PWT.

Main Results:

  • Obesity was present in 140 out of 504 pediatric HCM patients.
  • Obesity was significantly associated with increased posterior wall thickness (PWT) (p=0.0011).
  • No significant association was found between obesity and interventricular septal thickness (IVST) (p=0.12).

Conclusions:

  • Obesity is associated with increased posterior wall thickness (PWT) in children with hypertrophic cardiomyopathy (HCM).
  • Obesity does not appear to significantly affect interventricular septal thickness (IVST) in this pediatric population.
  • Future studies should explore the clinical implications of obesity-related LVH in children with HCM.

Keywords:
DefibrillatorHypertrophic cardiomyopathyObesitySudden death

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