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Updated: Aug 7, 2026
09:04
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
Published on: April 19, 2017
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens
H R MacDonald1, R Schneider, R K Lees
1Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
Nature
|March 3, 1988
Abstract:
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
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