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New oral liposomal vitamin C formulation: properties and bioavailability
Maciej Łukawski1, Paulina Dałek1,2, Tomasz Borowik2
1Department of Biomedical Engineering, Wroclaw University of Science and Technology, Wrocław, Poland.
Journal of Liposome Research
|July 3, 2019
Summary
This study introduces a novel liposomal vitamin C formulation, free of harsh solvents. This enhanced delivery method improves vitamin C
Area of Science:
- Biochemistry and Nutritional Science
- Nanotechnology in Medicine
Background:
- Vitamin C (ascorbic acid) is essential for numerous metabolic processes and maintaining homeostasis.
- Poor pharmacokinetics and low levels in processed foods necessitate continuous vitamin C supplementation.
- Traditional vitamin C formulations may involve harmful organic solvents.
Purpose of the Study:
- To develop and characterize a novel, solvent-free liposomal vitamin C formulation.
- To assess the cellular accessibility and bioavailability of vitamin C from this new formulation.
Main Methods:
- Quantitative chemical composition and nano-structuring analysis of the liposomal formulation.
- In vitro cell culture experiments to evaluate vitamin C accessibility.
- In vivo human clinical trials to demonstrate enhanced bioavailability.
Main Results:
- Successful development of a liposomal vitamin C formulation without harmful organic solvents.
- Demonstrated efficient cellular uptake of vitamin C from the liposomes in cell cultures.
- Significant enhancement in vitamin C bioavailability confirmed through clinical experimentation.
Conclusions:
- The novel liposomal formulation offers a safe and effective method for vitamin C delivery.
- This formulation overcomes limitations of conventional vitamin C supplementation, improving bioavailability.
- Potential for improved health outcomes due to enhanced vitamin C delivery.
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