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Natural Products from Mediterranean Diet: From Anti-hyperlipidemic Agents to Dietary Epigenetic Modulators

Deligiannidou Georgia-Eirini1, Sygkouna Athina1, Vanden Berghe Wim2

  • 1Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece.

Current Pharmaceutical Biotechnology
|July 3, 2019
PubMed

Insights

Natural products, especially from the Mediterranean diet, show promise in managing hyperlipidemia. Consistent consumption within a healthy lifestyle, potentially monitored by epigenetic biomarkers, is key for preventing cardiovascular diseases.

Area of Science:

  • Nutritional Science
  • Epigenetics
  • Cardiovascular Health

Background:

  • Cardiovascular diseases (CVD) are a leading cause of global mortality.
  • Hyperlipidemia (dyslipidemia) involves elevated blood lipids, increasing atherosclerosis risk.
  • Natural products offer alternative therapeutic strategies for hyperlipidemia, with growing interest in epigenetic mechanisms.

Purpose of the Study:

  • To provide a comprehensive overview of the anti-hyperlipidemic effects of natural products.
  • To focus on Mediterranean region natural products and their impact on gene expression and cardiometabolic pathways.
  • To explore the role of epigenetic changes in hyperlipidemia and dietary prevention.

Main Methods:

  • Searched PubMed, Scopus, and Google Scholar for articles published in the last five years.
  • Utilized keywords such as "hyperlipidemia", "plant extract", "natural products", and "cholesterol".
  • Included in vitro, animal studies, Randomized Controlled Trials (RCTs), and review articles.

Main Results:

  • Numerous natural products within the Mediterranean diet exhibit anti-hyperlipidemic properties.
  • The effectiveness of these natural products is often dose- and frequency-dependent.
  • Consistent dietary habits are crucial for reversing disease markers and managing hyperlipidemia.

Conclusions:

  • The Mediterranean diet offers natural products with significant anti-hyperlipidemic potential.
  • A healthy, consistent diet is vital for managing hyperlipidemia and preventing comorbidities.
  • Epigenetic biomarkers are emerging as valuable tools for monitoring dietary interventions and promoting healthy lifestyles.
Abstract

Keywords:
Mediterranean dietRandomized Controlled Trials (RCTs)epigeneticshyperlipidemiaplant extractsvegetables.

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