Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A clinical study on different cellulosic dialysis membranes.

D Falkenhagen1, T Bosch, G S Brown

  • 1Department of Internal Medicine, Wilhelm Pieck University, Rostock, GDR.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1987
PubMed
Summary

Modified cellulose membranes (Hemophan) offer comparable clearance to traditional options but significantly improve phosphate removal and blood compatibility. This enhanced biocompatibility, reducing complement activation and white blood cell reduction, stems from chemical modification, not heparin binding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Centronuclear myopathy. Histopathological aspects in ten patients with childhood onset.

Arquivos de neuro-psiquiatria·1998
Same author

Purification and biochemical analysis of WprA, a 52-kDa serine protease secreted by B. subtilis as an active complex with its 23-kDa propeptide.

Biochimica et biophysica acta·1998
Same author

A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

Neurobiology of disease·1998
Same author

Centronuclear myopathy: clinical aspects of ten Brazilian patients with childhood onset.

Journal of the neurological sciences·1998
Same author

Apamin improves spatial navigation in medial septal-lesioned mice.

European journal of pharmacology·1998
Same author

Congenital melanocytic nevi with placental infiltration by melanocytes: a benign condition that mimics metastatic melanoma.

Archives of dermatology·1998

Area of Science:

  • Biomaterials Science
  • Nephrology
  • Clinical Medicine

Background:

  • Dialysis membranes are crucial for hemodialysis efficacy and patient safety.
  • Classical regenerated cellulose (Cuprophan) and cellulose acetate membranes have known limitations in biocompatibility.
  • Modified cellulosic membranes aim to improve upon existing dialysis technologies.

Purpose of the Study:

  • To compare the clinical efficacy and blood compatibility of a modified cellulose membrane (Hemophan) against regenerated cellulose (Cuprophan) and cellulose acetate membranes.
  • To investigate the clearance rates for urea, creatinine, and inorganic phosphate.
  • To assess complement activation and white blood cell/platelet reduction.

Main Methods:

  • A controlled, 8-week cross-over clinical study in two dialysis centers.

Related Experiment Videos

  • Inclusion of dialyzers with Hemophan, Cuprophan, and cellulose acetate membranes.
  • Clinical and biochemical investigations, including clearance measurements and blood compatibility assessments (C3a activation, WBC and platelet counts).

    • Main Results:

    • Hemophan demonstrated comparable urea and creatinine clearance to Cuprophan and cellulose acetate.
    • Modified cellulose exhibited significantly increased inorganic phosphate clearance compared to both other membranes.
    • Hemophan showed significantly reduced complement activation (C3a) and white blood cell reduction versus Cuprophan and cellulose acetate.

    Conclusions:

    • Modified cellulose (Hemophan) offers comparable solute clearance to conventional membranes.
    • Hemophan provides superior blood compatibility by minimizing complement activation and white blood cell reduction.
    • The improved biocompatibility is attributed to the chemical modification of cellulose, not heparin binding.