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Updated: Jan 22, 2026
09:29
Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
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Controlled-release of fluazinam from biodegradable PLGA-based microspheres
Qi Wang1, Mengfei Shen2, Wenjing Li1
1College of Life Science and Bioengineering, Beijing University of Technology, Beijing, P.R. China.
Summary
Biodegradable nanoparticles effectively encapsulate the fungicide fluazinam, offering enhanced slow-release properties and superior antifungal activity against plant pathogens compared to traditional formulations.
Area of Science:
- Agricultural Science
- Materials Science
- Biotechnology
Background:
- Pesticides are crucial for managing agricultural pests and diseases.
- Encapsulation in biodegradable carriers offers slow-release benefits, improving pesticide performance.
- Poly (lactic-co-glycolic acid) (PLGA) nanoparticles are promising for controlled pesticide delivery.
Purpose of the Study:
- To develop and characterize poly (lactic-co-glycolic acid) (PLGA) nanoparticles for encapsulating the fungicide fluazinam (Flu).
- To evaluate the antifungal efficacy and release properties of encapsulated fluazinam against Rhizoctonia solani.
- To compare the performance of nanoparticle formulations with a commercial pesticide formulation.
Main Methods:
- Utilized the Shirasu Porous Glass (SPG) membrane emulsification method to prepare PLGA nanoparticles.
- Employed polyvinyl alcohol (PVA) and sodium dodecyl sulfate (SDS) as surfactants during nanoparticle synthesis.
- Characterized nanoparticle size, shape, and encapsulation efficiency.
- Assessed sustained-release properties, UV degradation resistance, storage stability, leaf surface coverage, and antifungal efficacy.
Main Results:
- Two types of PLGA nanoparticles (NPs) were successfully prepared with uniform spherical shapes, averaging 314.13 nm (SDS) and 612.80 nm (PVA).
- The encapsulated fluazinam exhibited excellent sustained-release properties.
- Nanoparticle formulations demonstrated superior resistance to UV degradation, enhanced storage stability, improved leaf surface coverage, and greater antifungal efficacy compared to the commercial formulation.
Conclusions:
- PLGA nanoparticles provide an effective system for the slow release of the fungicide fluazinam.
- Nanoparticle encapsulation significantly enhances the stability, efficacy, and delivery of fluazinam for agricultural applications.
- This approach offers a promising alternative to conventional pesticide formulations for improved crop protection.
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