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Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study
Feng Li1,2, Aiyou Mao1, Xianxian Fu1
1Department of Clinical Laboratory, Haikou People's Hospital, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, Hainan, China.
Journal of Clinical Laboratory Analysis
|July 3, 2019
Summary
Genetic variations in the selenoprotein S gene (SEPS1) were studied in a Chinese population. Certain SEPS1 gene polymorphisms, rs34713741 and rs4975814, show potential protective and susceptibility roles in diabetic nephropathy, respectively.
Area of Science:
- Genetics
- Molecular Biology
- Endocrinology
Background:
- The selenoprotein S (SEPS1) gene encodes a protein with anti-inflammatory and antioxidant properties, implicated in various diseases.
- Understanding SEPS1 gene distribution is crucial for studying its role in the Chinese diabetic population.
Purpose of the Study:
- To investigate the distribution characteristics of SEPS1 gene polymorphisms in Chinese individuals with diabetes mellitus (DM) and diabetic nephropathy (DN).
- To identify potential genetic markers associated with DM and DN in the studied population.
Main Methods:
- Genotyping of SEPS1 gene polymorphisms (rs4965814, rs28665122, rs34713741) using massARRAY and rs4965373 using Sanger sequencing.
- Analysis involved 170 patients with DM (including T2DM and DN) and 100 healthy controls (HC).
Main Results:
- Significant differences in genotype and allele distribution of rs34713741 were observed between DN and HC groups, and between T2DM and DN groups.
- The T allele of rs34713741 was associated with a reduced risk of DN (OR=0.60).
- Significant differences in genotype distribution of rs4975814 were found between DN and HC groups, with the T allele associated with an increased risk of DN (OR=2.71).
Conclusions:
- The SEPS1 gene polymorphism rs34713741 (GT + TT genotypes) may act as a protective factor against diabetic nephropathy.
- The SEPS1 gene polymorphism rs4975814 (GT + TT genotypes) may be a susceptibility factor for diabetic nephropathy.
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