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Updated: Jan 22, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
Numerical computation of rare events via large deviation theory
Tobias Grafke1, Eric Vanden-Eijnden2
1Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom.
Abstract:
An overview of rare event algorithms based on large deviation theory (LDT) is presented. It covers a range of numerical schemes to compute the large deviation minimizer in various setups and discusses best practices, common pitfalls, and implementation tradeoffs. Generalizations, extensions, and improvements of the minimum action methods are proposed. These algorithms are tested on example problems which illustrate several common difficulties which arise, e.g., when the forcing is degenerate or multiplicative, or the systems are infinite-dimensional. Generalizations to processes driven by non-Gaussian noises or random initial data and parameters are also discussed, along with the connection between the LDT-based approach reviewed here and other methods, such as stochastic field theory and optimal control. Finally, the integration of this approach in importance sampling methods using, e.g., genealogical algorithms, is explored.
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