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Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis
J E Patterson1, B L Masecar, M J Zervos
1Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
Antimicrobial Agents and Chemotherapy
|January 1, 1988
Abstract:
We identified two beta-lactamase-positive enterococci. One strain was high-level (MIC, greater than 2,000 microgram/ml) gentamicin resistant; the other was not (MIC, 12.5 microgram/ml). beta-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by beta-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.