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Polyol dehydrogenases: intermediate role in the bioconversion of rare sugars and alcohols
Fuzhi Lu1, Wei Xu1, Wenli Zhang2
1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Abstract:
Polyol dehydrogenases (PDHs) play a pivotal role in the biotransformation between rare sugar and alcohol. Among these PDHs, mannitol 2-dehydrogenase (MDH, EC 1.1.1.67), galactitol 2-dehydrogenase (GDH, EC 1.1.1.16), ribitol 2-dehydrogenase (RDH, EC 1.1.1.56), xylitol 4-dehydrogenase (XDH, EC 1.1.1.14), and arabitol 2-dehydrogenase (ArDH, EC 1.1.1.12) are the most studied. MDH can catalyze the transformation between D-fructose and mannitol as well as the transformation between D-arabitol and D-xylulose. In addition to MDH, the other PDHs including RDH, GDH, ArDH, and XDH are also important tools for the production of rare sugars including D-tagatose, allitol, D-xylulose, and L-xylulose. Concerning the intermediate function of PDH in the linkage of rare sugar and sugar alcohols, this review attempts to conclude their catalytic properties and potential applications.
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