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Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer

Jasmin Zeindler1, Fiorenzo Angehrn2, Raoul Droeser2

  • 1Breast Cancer Center, University Hospital Basel and University of Basel, 4031, Basel, Switzerland.

Breast Cancer Research and Treatment
|July 4, 2019
PubMed
Abstract

Insights

Myeloperoxidase (MPO)-positive cell infiltration in breast cancer indicates a better prognosis. This finding suggests MPO is a significant independent biomarker for improved overall survival in patients.

Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • Myeloperoxidase (MPO) is an enzyme released by neutrophils during inflammation.
  • MPO-expressing cell infiltration is linked to favorable prognosis in colorectal cancer.

Purpose of the Study:

  • To investigate the prognostic significance of MPO-positive cell infiltration in invasive breast cancer.
  • To determine if MPO-positive cell infiltration is an independent prognostic biomarker in breast cancer.

Main Methods:

  • Immunohistochemical staining for MPO was performed on tissue microarrays from 928 human breast cancer samples.
  • Clinical-pathological annotation and outcome data were analyzed.

Main Results:

  • MPO-positive cell infiltration was observed in 16% of breast cancer cases.
  • Univariate analysis revealed MPO-positive cell infiltration significantly improved overall survival (p < 0.001).
  • Multivariate analysis confirmed MPO expression as an independent prognostic factor for improved overall survival (p < 0.001).

Conclusions:

  • MPO-positive cell infiltration is a novel, independent prognostic biomarker for improved overall survival in breast cancer.
  • This study provides the first evidence of MPO's prognostic value in human breast cancer.
Keywords:
Breast cancerMyeloperoxidasePrognostic factorTumour-associated neutrophils

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