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Related Concept Videos

Schizophrenia01:17

Schizophrenia

824
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
824
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

533
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
533
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

492
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
492
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

499
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
499
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

514
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
514
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

580
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
580

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Related Experiment Video

Updated: Jan 22, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

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Neuroinflammation and Schizophrenia.

Peter F Buckley1

  • 1Virginia Commonwealth University School of Medicine, 1201 East Marshall St., 4th floor, Richmond, VA, 23298, USA. peter.buckley@vcuhealth.org.

Current Psychiatry Reports
|July 4, 2019
PubMed
Summary

Schizophrenia involves immune system dysfunction, particularly with cytokine abnormalities. Recent studies on genetics, immune markers, and treatments support the neuroimmune hypothesis of schizophrenia.

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Longstanding evidence suggests immune dysfunction in schizophrenia.
  • Peripheral immune markers, especially cytokine abnormalities, are frequently observed.

Purpose of the Study:

  • To review recent genetic and immune marker studies in schizophrenia.
  • To appraise emergent treatment studies related to the neuroimmune hypothesis.

Main Methods:

  • Literature review of genetic studies.
  • Analysis of immune marker research.
  • Synthesis of treatment trial outcomes.

Main Results:

  • Genetic and immune marker studies provide further support for immune system involvement.
Keywords:
CytokinesGeneticsImmune markersSchizophrenia

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  • Emerging treatments targeting immune pathways show potential.

    • Conclusions:

    • The neuroimmune hypothesis of schizophrenia is strengthened by recent findings.
    • Further research into immune system modulation may offer novel therapeutic strategies.