Robotic Pancreaticoduodenectomy Is Associated with Decreased Clinically Relevant Pancreatic Fistulas: a

Jianpeng Cai1, Rajesh Ramanathan2, Mazen S Zenati3

  • 1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Abstract

Insights

Robotic pancreatoduodenectomy (RPD) significantly reduces clinically relevant postoperative pancreatic fistula (CR-POPF) compared to open surgery. This study shows RPD minimizes the clinical impact of pancreatic leaks after this major procedure.

Area of Science:

  • Surgical Oncology
  • Minimally Invasive Surgery
  • Gastrointestinal Surgery

Background:

  • Pancreatoduodenectomy (PD) is a complex procedure with a high risk of complications.
  • Clinically relevant postoperative pancreatic fistula (CR-POPF) is a significant cause of morbidity after PD.
  • The robotic approach is hypothesized to reduce the incidence of CR-POPF.

Purpose of the Study:

  • To evaluate the impact of robotic PD (RPD) on CR-POPF.
  • To compare CR-POPF rates between open PD (OPD) and RPD.
  • To determine if RPD is an independent predictor of lower CR-POPF.

Main Methods:

  • A propensity-matched analysis of patients undergoing PD.
  • Comparison of CR-POPF outcomes between OPD and RPD groups.
  • Logistic regression and propensity score matching (PSM) were employed.

Main Results:

  • RPD was associated with a lower incidence of CR-POPF (6.7% vs. 15.8%, p < 0.001).
  • RPD was an independent predictor of lower CR-POPF on multivariate analysis (OR 0.278, p < 0.001).
  • PSM confirmed RPD's protective effect against CR-POPF (coefficient = -0.113, p = 0.001).

Conclusions:

  • RPD can minimize the clinical impact of pancreatic leaks after PD.
  • This study represents the largest single-center PSM analysis on robotic PD and CR-POPF.
  • The findings support the adoption of robotic surgery for PD to improve patient outcomes.

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