Related Experiment Video
Updated: Jan 22, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population-based
Zhen Zhai1,2, Fang Zhang3, Yi Zheng1,2
1Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Introduction:
It remains unclear whether marital status could affect the breast cancer-caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer.
Materials And Methods:
We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program. We assessed the effect of marital status on overall survival (OS) and BCSS using Kaplan-Meier curve and multivariate Cox proportional hazards regression.
Results:
Compared with divorced/separated/widowed (DSW) patients, the married (AHR 0.7483, 95% CI: 0.729-0.7682, P < 0.001) and single patients had better BCSS (AHR 0.9096, 95% CI: 0.8796-0.9406, P < 0.001). Married patients kept better prognosis among all age subgroups, while the better BCSS of single patients occurred only in groups older than 35 years. As for race and hormone receptor status (HRs), the better BCSS of single patients was only observed in white race (AHR 0.881, 95% CI: 0.8457-0.9177, P < 0.001) and patients with ER+/PR + status (AHR 0.8844, 95% CI: 0.8393-0.932, P < 0.001).
Conclusion:
Our findings demonstrated that married and single patients with breast cancer had better prognosis than their DSW counterparts. Age, race, and HRs could affect the correlation between marital status and BCSS.
Related Concept Videos
Marcia's Theory of Identity Status
Intracellular Hormone Receptors
Types of Hormones
Cancer Survival Analysis
Hormonal Regulation
Hormonal Regulation

