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Related Concept Videos

Hydrogen Bonds00:26

Hydrogen Bonds

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Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
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Hydrogen Bonds01:04

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A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

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Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation01:28

Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation

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Unlike the easy catalytic hydrogenation of an alkene double bond, hydrogenation of a benzene double bond under similar reaction conditions does not take place easily. For example, in the reduction of stilbene, the benzene ring remains unaffected while the alkene bond gets reduced. Hydrogenation of an alkene double bond is exothermic and a favorable process. In contrast, to hydrogenate the first unsaturated bond of benzene, an energy input is needed; that is, the process is endothermic. This is...
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Biofunctionalization of Magnetic Nanomaterials
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Micro/Nanomaterials-Augmented Hydrogen Therapy.

Gaoxin Zhou1, Ekta Goshi1, Qianjun He1

  • 1Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518071, Guangdong, China.

Advanced Healthcare Materials
|July 4, 2019
PubMed
Summary
This summary is machine-generated.

Hydrogen therapy shows promise for treating oxidative stress and inflammation. Nanomaterials can enhance hydrogen delivery and efficacy for improved therapeutic outcomes in various diseases.

Keywords:
antioxidationhydrogen therapyinflammationnanomaterialsreactive oxygen species

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Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Therapeutic Agents

Background:

  • Hydrogen therapy utilizes molecular hydrogen for treating oxidative stress and inflammation-related diseases.
  • Hydrogen gas is a safe therapeutic agent, unlike other gaseous transmitters, with no risk of blood poisoning.
  • Challenges in hydrogen therapy include limited efficacy due to low solubility and uncontrolled diffusion.

Purpose of the Study:

  • To propose hydrogen nanomedicine as a strategy to overcome limitations in hydrogen therapy.
  • To review methods for augmenting hydrogen therapy using micro/nanomaterials.
  • To explore targeted delivery, controlled release, and enhanced efficacy of hydrogen therapy.

Main Methods:

  • Review of micro/nanomaterials-mediated targeted hydrogen delivery strategies.
  • Summary of controlled hydrogen release mechanisms using nanomaterials.
  • Discussion of nanocatalytic and multimodal enhancement of hydrogen therapy.

Main Results:

  • Micro/nanomaterials offer solutions for site-specific hydrogen delivery and controlled release.
  • Nanocatalysis and multimodal approaches can significantly enhance hydrogen therapy efficacy.
  • Augmented hydrogen therapy using nanomedicine shows potential for treating inflammation-related diseases.

Conclusions:

  • Hydrogen nanomedicine presents a novel approach to enhance hydrogen therapy.
  • Functional micro/nanomaterials are key to improving targeted delivery and controlled release of hydrogen.
  • This strategy opens new therapeutic possibilities for oxidative stress and inflammation-related diseases.