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Updated: Jan 22, 2026

Preparing Silica Aerogel Monoliths via a Rapid Supercritical Extraction Method
Published on: February 28, 2014
Epinephrine-modified methacrylate monolithic column with fumed silica nanoparticle for pressurized capillary
Hong Pan1, Rangdong Liu1, Soumia Cheddah1
1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China.
Abstract:
Via the ring-opening reaction of epoxy groups with epinephrine, a novel epinephrine functionalized polymethacrylate monolith with fumed silica nanoparticles has been fabricated for pressurized capillary electrochromatography. The preparation of epinephrine-modified monoliths has been optimized. In addition, morphology, electroosmotic flow, separation mechanism and column performance have been studied. The internal structure of the monolithic stationary phase was more uniform and the column efficiency increased after the incorporation of nanoparticles. With this column, satisfactory separation capability of aromatic compounds and alkaloids has been achieved and the column efficiency for naphthalene reached 138 696 plates/m. As for the real sample, 3 alkaloids were separated in Huanglian Shangqing capsules, a Chinese traditional medicine.
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