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Related Concept Videos

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Consider a real-valued function defined on a closed interval. One of the fundamental objectives in calculus is to determine the area under the graph of such a function. When an exact computation is not readily available, this area can be estimated by dividing the interval into a finite number of equal subintervals. Each subinterval corresponds to a rectangle whose width is the length of the subinterval and whose height is determined by the value of the function at a selected point within that...
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The water inflow rate into a storage tank is not constant but increases over time. Initially, the pump delivers water at a rate of 5 L/min. However, the inflow rate increases by 2 L/min for each additional minute due to rising pressure or system adjustments. This scenario can be described mathematically by a linear function:It is necessary to integrate the inflow rate function to measure the total volume of water added to the tank over time. The total water volume V(t) is obtained by performing...
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An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
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Updated: Jan 22, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
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Label-Free Exosome Detection Based on a Low-Cost Plasmonic Biosensor Array Integrated with Microfluidics.

Xiaoqing Lv1, Zhaoxin Geng1,2, Yue Su1,3

  • 1State Key Laboratory of Integrated Opoelectronics, Institute of Semiconductors , Chinese Academy of Sciences , Beijing 100083 , China.

Langmuir : the ACS Journal of Surfaces and Colloids
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Summary
This summary is machine-generated.

This study presents a novel plasmonic biosensor array for label-free exosome detection. The low-cost, portable device achieved a detection limit of 1 ng/mL, showing potential for noninvasive disease diagnosis.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Localized surface plasmon resonance (LSPR) biosensors offer portable, real-time, label-free detection.
  • Exosomes are crucial biomarkers for noninvasive disease diagnosis.
  • Microfluidic integration enhances biosensor capabilities.

Purpose of the Study:

  • To develop a microfluidic-integrated plasmonic biosensor array for label-free exosome detection.
  • To fabricate gold nano-ellipsoid arrays using cost-effective methods.
  • To demonstrate the platform's potential for biomarker detection and disease diagnosis.

Main Methods:

  • Fabrication of gold nano-ellipsoid arrays on anodic aluminum oxide thin films.
  • Integration of nano-ellipsoid arrays with a microfluidic chip.
  • Surface modification with anti-CD63 antibodies for exosome capture.
  • Detection of exosomes using LSPR shifts.

Main Results:

  • Successful label-free detection of exosomes at various concentrations.
  • Achieved a low detection limit of 1 ng/mL.
  • Demonstrated multiparameter detection capability by changing surface antibodies.

Conclusions:

  • The developed plasmonic biosensor array is a versatile platform for exosome and biomarker detection.
  • The low-cost, portable design holds promise for noninvasive disease diagnostics.
  • This technology can be adapted for detecting various biomarkers by modifying surface chemistry.